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Table of Contents |
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Part I. MOLECULAR AND CELLULAR BASIS OF HEMATOLOGY
Chapter 1: Anatomy and Physiology of the Gene
Chapter 2: Genomic Approaches to the Study of Hematologic Science
Chapter 3: Protein Synthesis, Processing, and Degradation
Chapter 4: Protein Architecture: Relationship of Form and Function
Chapter 5: Regulation of Cellular Response
Chapter 6: Cell Adhesion
Chapter 7: Control of Cell Division
Chapter 8: Cell Death
Chapter 9: Pharmacogenomics and Hematological Diseases
Part II. IMMUNOLOGIC BASIS OF HEMATOLOGY
Chapter 10: Overview and Compartmentalization of the Immune System
Chapter 11: B-Cell Development
Chapter 12: T-Cell and NK-Cell Immunity
Chapter 13: Dendritic Cell Biology
Chapter 14: Regulation of Activation of B and I Lymphocytes
Chapter 15: Leukocyte Trafficking
Chapter 16: Tolerance and Autoimmunity
Part III. BIOLOGY OF STEM CELLS AND DISORDERS OF HEMATOPOIESIS
Chapter 17: Stem Cell Model of Hematopoiesis
Chapter 18: Bone Marrow Microenvironment
Chapter 19: The Humeral Regulation of Hematopoiesis
Chapter 20: Biology of Erythropoiesis, Erythroid Differentiation, and Maturation
Chapter 21: Granulopoiesis and Monocytopoiesis
Chapter 22: Thrombocytopoiesis
Chapter 23: Thrombocytopenia Due to Decreased Platelet Production
Chapter 24: Inherited Forms of Bone Marrow Failure
Chapter 25: Aplastic Anemia
Chapter 26: Paroxysmal Nocturnal Hemoglobinuria
Chapter 27: Pure Red Cell Aplasia
Part IV. RED BLOOD CELLS
Chapter 28: Pathobiology of the Human Erythrocyte and Its Hemoglobins
Chapter 29: Approach to Anemia in the Adult and Child
Chapter 30: Anemia of Chronic Diseases
Chapter 31: Pathology of Iron Metabolism
Chapter 32: Disorders of Iron Metabolism: Iron Deficiency and Overload
Chapter 33: Heme Biosynthesis and Its Disorders: Porphyrias and Sideroblastic Anemias
Chapter 34: Megablastic Anemias
Chapter 35: Thalassemia Syndromes
Chapter 36: Pathology of Sickle Cell Disease
Chapter 37: Sickle Cell Disease
Chapter 38: Hemoglobin Variants Associated with Hemolytic Anemia, Altered Oxygen Affinity, and Methemoglobinemias
Chapter 39: Red Cell Enzymopathies
Chapter 40: Red Cell Membrane Disorders
Chapter 41: Autoimmune Hemolytic Anemias
Chapter 42: Extrinsic Nonimmune Hemolytic Anemias
Part V. HOST DEFENSE AND ITS DISORDERS
Chapter 43: Complement Biology and Immunoglobulin
Chapter 44: Normal Phagocyte Structure and Function
Chapter 45: Eosinophilia, Eosinophil-Associated Diseases, Chronic Eosinophil Leukemia, and the Hypereosinophilic Syndromes
Chapter 46: Disorders of Phagocyte Function and Number
Chapter 47: Disorders of Lymphocyte Function
Chapter 48: Histiocytic Disorders
Chapter 49: Lysosomal Storage Diseases: Perspective and Principles
Chapter 50 Infectious Mononucleosis and Other Epstein-Barr Virus-Associated Diseases
Chapter 51: The Spleen and Its Disorders
Chapter 52: Basophils, Mast Cells, and Systemic Mastocytosis
Part VI. HEMATOLOGIC MALIGNANCIES
Chapter 53: Conventional Cytogenetics and Molecular Cytogenetics in Hematological Malignancies
Chapter 54: The Molecular Basis of Neoplasia
Chapter 55: Pharmacology and Molecular Mechanisms of Antineoplastic Agents for Hematologic Malignancies
Chapter 56: Radiation Therapy in the Treatment of Hematologic Malignancies
Chapter 57: Clinical Use of Hematopoietic Growth Factors
Chapter 58: Radioimmunotherapy for B-Cell and Non-Hodgkin Lymphoma
Chapter 59: Pathobiology of Acute Myeloid Leukemia
Chapter 60: Clinical Manifestations of Acute Myeloid Leukemia
Chapter 61: Therapy for Acute Myeloid Leukemia
Chapter 62: Acute Myeloid Leukemia in Children
Chapter 63: Pathobiology of Acute Lymphoblastic Leukemia
Chapter 64: Clinical Manifestations of Acute Lymphoblastic Leukemia
Chapter 65: Treatment of Childhood Acute Lymphoblastic Leukemia
Chapter 66: Acute Lymphoblastic Leukemia in Adults
Chapter 67: Myelodysplastic Syndrome: Biology and Treatment
Chapter 68: Polycythemia Vera
Chapter 69: Chronic Myeloid Leukemia
Chapter 70: Myelofibrosis with Myeloid Metaplasia
Chapter 71: Essential Thrombocythemia
Chapter 72: Myelodysplastic Syndromes and Myeloproliferative Syndromes in Children
Chapter 73: Pathobiology of Non-Hodgkin Lymphomas
Chapter 74: Patho-Biology of Hodgkin’s Lymphoma
Chapter 75: Hodgkin’s Disease: Clinical Manifestations, Staging, and Therapy
Chapter 76: The Pathologic Basis for the Classification of Non-Hodgkin Lymphomas
Chapter 77: Clinical Manifestations, Staging, and Treatment of Non-Hodgkin Lymphoma
Chapter 78: Malignant Lymphomas in Childhood
Chapter 79: Chronic Lymphocytic Leukemia
Chapter 80: Hairy Cell Leukemia
Chapter 81: Cutaneous T-Cell Lymphomas
Chapter 82: AIDS-Related Lymphomas
Chapter 83: Multiple Myeloma and Other Plasma Cell Disorders
Chapter 84: Immunoglobulin Light Chain Amyloidosis (Primary Amyloidosis, AL)
Chapter 85: Atypical Immune Lymphoproliferations
Chapter 86: Clinical Approaches to Infections in the Compromised Host
Chapter 87: Nutritional Support of Patients with Hematologic Malignancies
Chapter 88: Psychosocial Aspects of Hematologic Disorders
Chapter 89: Pain Management and Antiemetic Therapy in Hematologic Disorders
Chapter 90: Palliative Care
Chapter 91: Indwelling Access Devices
Chapter 92: Late Complications of Hematologic Diseases and Their Therapies
Part VII. TRANSPLANTATION
Chapter 93: Hematopoietic Stem Cell Transplantation for Acquired Nonmalignant Diseases and Myelodysplastic Syndrome
Chapter 94: Hematopoietic Cell Transplant for Immune Deficiences and Genetic Diseases
Chapter 95: Results of Allogeneic Hematopoietic Cell Transplant for Hematologic Malignancies
Chapter 96: Autologous Transplant for Hematologic malignancies and Solio Tumors
Chapter 97: Unrelated Donor Stem Cell Transplantation Therapy Anasetti
Chapter 98: Umbilical Cord Blood Transplantation
Chapter 99: Preparative Regimens for Hematopoietic Cell Transplantation
Chapter 100: Graft-versus-Host Disease and Graft-versus-Leukemia
Chapter 101: Graft Engineering to Enhance Engraftment, Reduce Graft-versus-Host Disease and Provide a Graft-versus-Tumor Effect
Chapter 102: Gene Transfer for Hematologic Disorders
Chapter 103: Experimental Cell Therapy
Chapter 104: Complications After Hematopoietic Cell Transplantation
Part VIII. HEMOSTASIS AND THROMBOSIS
Chapter 105: Megakaryocyte and Platelet Structure
Chapter 106: The Molecular Basis for Platelet Function
Chapter 107: The Molecular Basis for Platelet Activation
Chapter 108: The Blood Vessel Wall
Chapter 109: Molecular Basis of Blood Coagulation
Chapter 110: Molecular and Cellular Basis of Fibrinolysis
Chapter 111: Regulatory Mechanisms in Hemostasis: Natural Anticoagulants
Chapter 112: Clinical Evaluation of Hemorrhagic Disorders: Bleeding History and Differential Diagnosis of Pupura
Chapter 113: Laboratory Evaluation of Hemostatic Disorders
Chapter 114: Structure, Biology, and Genetics of Factor VIII
Chapter 115: Biochemistry of Factor IX and Molecular Biology of Hemophilia B
Chapter 116: Clinical Aspects and Therapy of Hemophilia
Chapter 117: Inhibitors in Hemophilia
Chapter 118: Other Clotting Factor Deficiencies
Chapter 119: Disorders of Fibrinogen
Chapter 120: Structure, Biology, and Genetics of von Willebrand Factor
Chapter 121: von Willebrand Disease: Clinical Aspects and Therapy
Chapter 122: Vitamin K: Metabolism and Disorders
Chapter 123: Inhibitors of Blood Coagulation
Chapter 124: Disseminated Intrvascular Coagulation
Chapter 125: Hemostatic Defects Associated with Dysproteinemias
Chapter 126: Disorders of Coagulation in the Neonate
Chapter 127: Hypercoagulable States
Chapter 128: Venous Thromboembolism
Chapter 129: Arterial Thromboembolism
Chapter 130: Anticoagulation and Thrombolytic Therapy
Chapter 131: Immune Thrombocytopenic Purpura, Neonatal Alloimmune Thrombocytopenia, and Posttransfusion Purpura
Chapter 132: Thrombotic Thrombocytopenic Purpura and the Hemolytic Uremic Syndrome
Chapter 133: Thrombocytopenia Due to Platelet Destruction and Hypersplenism
Chapter 134: Hereditary Disorders of Platelet Function
Chapter 135: Acquired Disorders of Platelet Function
Part IX. TRANSFUSION MEDICINE
Chapter 136: Human Blood Group Anitgens and Antibodies - Part 1: Carbohydrate Determinants - Part 2: Protein Determinants
Chapter 137: Human Platelet Antigens
Chapter 138: Human Leukocyte Antigen (HLA) and Human Neutrophil Antigen (HNA) Systems
Chapter 139: Principles of Red Blood Cell Transfusion
Chapter 140: Principles of Platelet Transfusion Therapy
Chapter 141: Principles of Neutrophil (Granulocyte) Transfusions
Chapter 142: Transfusion of Plasma Derivatives: Fresh-Frozen Plasma, Cryoprecipitate, Albumin, and Immunoglobulins
Chapter 143: Preparation of Plasma-Derived and Recombinant Human Plasma Proteins
Chapter 144: Transfusion Therapy for Coagulation factor Deficiencies
Chapter 145: Hemapheresis and Cellular Therapy
Chapter 146: Practical Aspects of Stem Cell Collection
Chapter 147: Transfusion Reactions
Chapter 148: Transfusion-Transmitted Diseases
Chapter 149: Transfusion Medicine in Hematopoietic Stem Cell and Solid Organ Transplantation
Chapter 150: Red Blood Cell Substitutes
Part X. CONSULTATIVE HEMATOLOGY
Chapter 151: Hematologic Manifestations of Systemic Disease: Liver and Renal Disease
Chapter 152: Hematologic Manifestations of Systemic Disease: Infection, Chronic Inflammation, and Cancer
Chapter 153: Hematologic Manifestations of AIDS
Chapter 154: Hematologic Problems in the Surgical Patient: Bleeding and Thrombosis
Chapter 155: Hematologic Aspects of Pregnancy
Chapter 156: Hematologic Manifestations of Childhood Illness
Part XI. SPECIAL TESTS AND PROCEDURES
Chapter 157: Bone Marrow Examination
Chapter 158: Automated Analysis of Blood Cells
Chapter 159: Laboratory Detection of Hemoglobinopathies and Thalassemias
Chapter 160: Antenatal Diagnosis of Hematologic Disorders
Chapter 161: Use of Molecular Techniques in the Analysis of Hematologic Diseases
Chapter 162: Molecular Imaging in Hematology
Appendix - Normal Blood Values: Selected Reference Values for Neonatal, Pediatric, and Adult Populations
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